This chemical is widely used as a derivatization agent in analytical chemistry, particularly in gas chromatography (GC) and mass spectrometry (MS). It reacts with carbonyl compounds, such as aldehydes and ketones, to form stable oxime derivatives, which enhances their detectability and separation during analysis. This is especially useful in the quantification of trace levels of carbonyl compounds in complex matrices like environmental samples, food products, and biological fluids. Its pentafluorobenzyl group improves sensitivity in electron capture detection (ECD) and negative ion chemical ionization (NICI) MS, making it a valuable tool for high-precision analytical methods. Additionally, it is employed in research studies to investigate metabolic pathways involving carbonyl-containing metabolites.