Lithium chloride solution is widely used in air conditioning and humidity control systems due to its strong hygroscopic properties. It efficiently absorbs moisture from the air, making it valuable in industrial dehumidifiers, especially in environments requiring low humidity levels such as pharmaceutical production, food processing, and material drying.

It is also employed in the synthesis of lithium-based chemicals and as an electrolyte in certain types of batteries and electrochemical applications. In research laboratories, lithium chloride solution serves as a source of chloride ions or lithium ions in chemical reactions and biological experiments, including RNA isolation and cell culture protocols.

Additionally, it finds use in the ceramics and glass industries to modify melting behavior and improve product quality. Its ability to lower the freezing point of water makes it suitable for use in some antifreeze formulations and de-icing solutions, though this application is less common due to cost and environmental considerations.