Used as a solvent in organic synthesis, especially for reactions involving sensitive or reactive compounds due to its high polarity and ability to stabilize cations. Commonly employed in peptide synthesis to prevent aggregation and improve solubility of intermediates. Facilitates fluorination reactions and is used in the preparation of fluorinated pharmaceuticals and agrochemicals. Also applied in polymer chemistry to dissolve and process fluoropolymers and other specialty polymers. Serves as a mobile phase additive in HPLC for improved separation of polar compounds. Its unique solvation properties make it useful in studying protein folding and biomolecular structure by NMR spectroscopy.