Chlorotriphenylsilane is widely used as a key reagent in organic synthesis, particularly in the preparation of silyl ethers. It serves as a protective group for alcohols, enabling selective reactions in complex molecule construction. Additionally, it is employed in the synthesis of organosilicon compounds, which are essential in the production of silicones and other polymers. In materials science, it is utilized for surface modification, enhancing the properties of various substrates. Its role in cross-coupling reactions also makes it valuable in pharmaceutical and agrochemical research.