Chloropentamethyldisilane is primarily used in the field of organic synthesis and materials science. It serves as a key reagent in the preparation of silicon-containing compounds, particularly in the modification of surfaces and the creation of silicon-based polymers. Its application is significant in the development of coatings and adhesives, where it enhances properties such as water resistance and durability. Additionally, it is utilized in the semiconductor industry for the deposition of silicon-based thin films, which are critical in the fabrication of electronic devices. The compound also finds use in the synthesis of organosilicon intermediates, which are essential in the production of silicones and other advanced materials.