(R,R,S)-DiazaPhos-PPE is primarily used as a chiral ligand in asymmetric catalysis, particularly in transition metal-catalyzed reactions. Its application is significant in the synthesis of enantiomerically pure compounds, which are crucial in the pharmaceutical industry for producing active pharmaceutical ingredients (APIs) with high stereoselectivity. This ligand is effective in reactions such as hydrogenation, hydroformylation, and carbon-carbon bond-forming reactions, where it helps achieve high enantiomeric excess (ee) and yield. Additionally, it is employed in academic and industrial research to develop new catalytic processes and optimize existing ones for the production of fine chemicals and intermediates.