(S)-(-)-1-(1-Naphthyl)ethyl isothiocyanate is primarily utilized in the field of organic synthesis, chiral analysis, and chemical research. It serves as a key chiral building block and derivatizing agent for the preparation of various biologically active compounds and for the enantiomeric resolution of primary amines and amino acids by HPLC. Its isothiocyanate group makes it a valuable reagent for the synthesis of thiourea derivatives, which are often explored for their potential pharmaceutical applications. Additionally, it is used in the development of chiral ligands and catalysts, aiding in asymmetric synthesis processes. The compound is also employed in the study of enzyme inhibition and receptor binding due to its ability to interact with biological targets. Its applications extend to material science, where it is used in the modification of surfaces and the creation of functionalized polymers.