D-tert-Leucine Methyl Ester Hydrochloride is primarily used in the pharmaceutical industry as a chiral building block for the synthesis of various bioactive compounds. Its sterically hindered structure makes it valuable in the development of peptide-based drugs, where it helps enhance stability and bioavailability. It is also employed in the preparation of enzyme inhibitors and receptor antagonists, particularly in research targeting neurological and metabolic disorders. Additionally, this compound is utilized in organic synthesis to introduce chiral centers, aiding in the creation of enantiomerically pure substances for medicinal chemistry applications. Its role in asymmetric synthesis further supports the production of high-purity intermediates for drug development.