(R)-BPO-27 is a chiral small molecule and selective modulator of the ryanodine receptor type 1 (RyR1), functioning as a stabilizer to prevent calcium leaks. It is widely used in biomedical and pharmacological research to study calcium signaling pathways implicated in various diseases. Key applications include preclinical studies for Duchenne muscular dystrophy, where it mitigates sarcoplasmic reticulum calcium leak; cancer research, demonstrating potential to inhibit tumor cell proliferation; and neurological disorders affecting the central nervous system, such as psychiatric and neurodegenerative conditions, due to RyR1's role in neuronal calcium homeostasis. As a research tool compound, it supports the development of therapeutics targeting aberrant calcium handling.