S-(-)-2,2-Dibromo-1,1'-binaphthyl is an axially chiral biaryl compound serving as a key intermediate for synthesizing chiral phosphine ligands, such as BINAP and its derivatives. The bromine atoms at the 2,2'-positions enable selective functionalization through palladium-catalyzed cross-coupling reactions (e.g., with diphenylphosphine) to introduce donor groups, yielding highly effective chiral catalysts. These ligands are essential in asymmetric catalysis for enantioselective hydrogenation, C-C bond formation, and other reactions critical to pharmaceutical and fine chemical production, where precise stereocontrol is required. Its inherent chirality is preserved in derived ligands, advancing stereoselective synthesis and chiral material development.