(S)-VAPOL is primarily used as a chiral ligand in asymmetric synthesis, particularly in catalytic reactions where high enantioselectivity is required. It is often employed in the development of pharmaceuticals, where the production of enantiomerically pure compounds is crucial for efficacy and safety. The ligand is effective in various transition metal-catalyzed reactions, such as asymmetric hydrogenation and carbon-carbon bond-forming reactions, enabling the synthesis of complex molecules with precise stereochemistry. Its application is also explored in the field of material science, where chiral catalysts are used to create advanced materials with specific optical properties.