(S)-2-((R)-1-(Diphenylphosphanyl)piperidin-2-yl)-4-phenyl-4,5-dihydrooxazole
97%
Reagent
Code: #233567
CAS Number
2757084-58-3
blur_circular Chemical Specifications
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Molecular Information
Weight
414.48 g/mol
Formula
C₂₆H₂₇N₂OP
thermostat
Physical Properties
Boiling Point
557.8±60.0 °C(Predicted)
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Storage & Handling
Storage
2-8°C, light-proof, inert gas
description Product Description
Widely used as a chiral ligand in asymmetric catalysis, this compound plays a key role in enantioselective hydrogenation reactions. It is particularly effective in the synthesis of chiral amines and amino acid derivatives, which are important intermediates in pharmaceutical manufacturing. Due to its rigid oxazoline-piperidine backbone and tunable phosphine group, it forms highly selective complexes with transition metals like rhodium and iridium. These catalysts enable high enantiomeric excess (ee) in transformations such as the asymmetric reduction of olefins and imines. Its application is prominent in the production of bioactive molecules where stereochemistry is critical for activity.
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