Used as a chiral auxiliary or ligand in asymmetric synthesis, particularly in catalytic enantioselective reactions. Its rigid oxazoline core and stereodefined centers make it effective in controlling stereochemistry during carbon–carbon bond-forming reactions. Commonly employed in transition metal-catalyzed transformations such as Heck couplings, Diels–Alder reactions, and conjugate additions, where it helps achieve high enantiomeric excess. The trifluoromethylpyridine moiety enhances ligand stability and influences electronic properties, improving catalyst performance under mild conditions. Also explored in pharmaceutical intermediates synthesis where precise stereocontrol is required.