(2R,3S)-3-(tert-butyl)-2-(di-tert-butylphosphino)-4-methoxy-2,3-dihydrobenzo[d][1,3]oxaphosphole
97%
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Widely used as a chiral ligand in asymmetric catalysis, this compound plays a key role in enantioselective transformations such as hydrogenation, cross-coupling, and C–H activation reactions. Its sterically bulky tert-butyl groups and rigid backbone enhance stereocontrol, leading to high enantiomeric excess in the synthesis of pharmaceuticals and fine chemicals. It is particularly effective in palladium- and rhodium-catalyzed reactions where precise chirality transfer is required. The presence of the methoxy group fine-tunes electron density at the phosphorus center, improving catalyst stability and reactivity. Due to its strong coordination and well-defined chiral environment, it enables efficient synthesis of complex molecules in academic and industrial research settings.
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