The (R,R)-DACH-naphthyl Trost ligand is widely used in asymmetric catalysis, particularly in enantioselective synthesis. It plays a crucial role in facilitating carbon-carbon bond-forming reactions, such as allylic alkylations and other transition metal-catalyzed processes. Its application is prominent in the pharmaceutical industry, where it aids in the production of chiral molecules with high enantiomeric purity, essential for active pharmaceutical ingredients (APIs). Additionally, it is employed in academic research to develop novel synthetic methodologies for complex organic compounds. The ligand’s ability to induce high stereoselectivity makes it a valuable tool in the synthesis of natural products and fine chemicals.