Used as a chiral derivatizing agent in the resolution of enantiomers, particularly in high-performance liquid chromatography (HPLC). Its structure allows for strong UV detection due to the naphthalene ring, making it effective for detecting and separating chiral compounds in pharmaceutical analysis. Commonly applied in the synthesis and purification of enantiomerically pure drugs, especially those containing carboxylic acid or amine functional groups. Also utilized in asymmetric synthesis as an auxiliary to control stereochemistry during key bond-forming reactions. Its trifluoromethyl group enhances lipophilicity and metabolic stability, beneficial in medicinal chemistry applications.