(R)-(-)-1-Aminoindane finds its primary application in the field of organic synthesis, particularly as a chiral building block. It is often utilized in the preparation of enantiomerically pure compounds, which are crucial in the development of pharmaceuticals. The compound's chiral nature makes it valuable for creating active pharmaceutical ingredients (APIs) with specific stereochemical requirements, enhancing the efficacy and reducing the side effects of drugs.

Additionally, (R)-(-)-1-Aminoindane is employed in the synthesis of various ligands and catalysts used in asymmetric catalysis. This application is significant in producing complex molecules with high enantiomeric purity, which is essential in industries such as agrochemicals and fine chemicals. Its role in these processes helps in achieving more efficient and selective chemical reactions, contributing to advancements in synthetic chemistry.

In research, this compound is also explored for its potential in neuroscience studies, particularly in understanding neurotransmitter systems and developing compounds that interact with these systems. Its structural similarity to certain pharmacologically active molecules makes it a candidate for studying receptor binding and activity, aiding in the discovery of new therapeutic agents.