Corey lactone diol is a key chiral intermediate in the synthesis of prostaglandins, which are biologically active compounds involved in inflammation, blood flow, and reproductive functions. Its well-defined stereochemistry allows for precise construction of prostaglandin structures, making it invaluable in pharmaceutical research and development. It is widely used in the multi-step synthesis of prostaglandin analogs such as latanoprost, travoprost, and bimatoprost—medications used to treat glaucoma and ocular hypertension. The diol functionality enables selective chemical modifications, facilitating the introduction of side chains and functional groups needed for biological activity. Due to its reliability and efficiency in asymmetric synthesis, Corey lactone diol remains a cornerstone in the industrial production of prostaglandin-based therapeutics.