2,2'-(4,10-Bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetic acid

95%

Reagent Code: #141055
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CAS Number 913542-71-9

science Other reagents with same CAS 913542-71-9

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 516.63 g/mol
Formula C₂₄H₄₄N₄O₈
thermostat Physical Properties
Boiling Point 644.7±55.0 °C(Predicted)
inventory_2 Storage & Handling
Density 1.133±0.06 g/cm3(Predicted)
Storage 2-8°C, Inert Gas

description Product Description

This compound serves as a key intermediate in the synthesis of macrocyclic chelating agents for medical imaging applications, such as MRI contrast agents and radiopharmaceuticals. It is a partially protected derivative of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), featuring two free acetic acid groups at the 1 and 7 positions for initial metal ion coordination and two tert-butyl ester groups at the 4 and 10 positions to facilitate synthetic handling and selective functionalization. The structure enables stable complexation with lanthanide ions like gadolinium (Gd3+), which, after full deprotection, provides high thermodynamic stability and kinetic inertness, minimizing free metal ion release and associated toxicity risks. This enhances MRI image clarity and diagnostic precision. In radiopharmaceuticals, it supports conjugation to targeting vectors for specific delivery of diagnostic or therapeutic radioisotopes, improving in vivo pharmacokinetics and biodistribution.

shopping_cart Available Sizes & Pricing

Size Availability Unit Price Quantity
inventory 100mg
10-20 days ฿6,240.00
inventory 250mg
10-20 days ฿10,590.00

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2,2'-(4,10-Bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetic acid
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This compound serves as a key intermediate in the synthesis of macrocyclic chelating agents for medical imaging applications, such as MRI contrast agents and radiopharmaceuticals. It is a partially protected derivative of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), featuring two free acetic acid groups at the 1 and 7 positions for initial metal ion coordination and two tert-butyl ester groups at the 4 and 10 positions to facilitate synthetic handling and selective functionalization.

This compound serves as a key intermediate in the synthesis of macrocyclic chelating agents for medical imaging applications, such as MRI contrast agents and radiopharmaceuticals. It is a partially protected derivative of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), featuring two free acetic acid groups at the 1 and 7 positions for initial metal ion coordination and two tert-butyl ester groups at the 4 and 10 positions to facilitate synthetic handling and selective functionalization. The structure enables stable complexation with lanthanide ions like gadolinium (Gd3+), which, after full deprotection, provides high thermodynamic stability and kinetic inertness, minimizing free metal ion release and associated toxicity risks. This enhances MRI image clarity and diagnostic precision. In radiopharmaceuticals, it supports conjugation to targeting vectors for specific delivery of diagnostic or therapeutic radioisotopes, improving in vivo pharmacokinetics and biodistribution.

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