JG-98 is a selective allosteric inhibitor of the heat shock protein 70 (Hsp70) family. It is primarily used in research settings to study the role of Hsp70 in cellular processes such as protein folding, degradation, and stress response. By inhibiting Hsp70, JG-98 disrupts cancer cell survival pathways, making it a valuable tool in oncology research, particularly in studies focused on overcoming drug resistance and inducing apoptosis in tumor cells. It has shown synergistic effects when combined with other anticancer agents, enhancing the efficacy of chemotherapy in preclinical models. JG-98 is also used to investigate Hsp70 involvement in neurodegenerative diseases, where protein misfolding and aggregation are key pathological features. Its ability to modulate proteostasis makes it a compound of interest in developing therapies for conditions like Alzheimer’s and Parkinson’s disease.