(E)-2-Hydroxychalcone is widely studied for its biological activities, making it valuable in pharmaceutical and medicinal research. It exhibits antioxidant properties, which help in neutralizing free radicals and reducing oxidative stress, potentially aiding in the prevention of diseases linked to oxidative damage. Additionally, it has shown anti-inflammatory effects, making it a candidate for developing treatments for inflammatory conditions. Its anticancer potential is also being explored, as it may inhibit the growth of cancer cells and induce apoptosis. In cosmetic formulations, it is used for its skin-protective benefits, particularly in combating UV-induced damage and aging. Furthermore, (E)-2-Hydroxychalcone is utilized in organic synthesis as a precursor for various bioactive compounds, contributing to the development of new drugs and therapeutic agents.