Norethindrone is widely used in hormonal contraception, often as a component of birth control pills. It helps prevent ovulation, thickens cervical mucus to block sperm, and thins the uterine lining to reduce the likelihood of implantation. Additionally, it is prescribed to treat menstrual disorders such as irregular periods, endometriosis, and abnormal uterine bleeding. In hormone replacement therapy, it is used to manage symptoms of menopause by balancing estrogen levels. It also plays a role in preventing endometrial hyperplasia in postmenopausal women undergoing estrogen therapy.