Tigecycline is used to treat a variety of bacterial infections, particularly those caused by multidrug-resistant organisms. It is effective in treating complicated skin and soft tissue infections, as well as complicated intra-abdominal infections. Due to its broad-spectrum activity, it is often reserved for cases where other antibiotics have failed or when the infecting bacteria are known or suspected to be resistant to multiple drugs. Tigecycline is also used off-label in the treatment of certain hospital-acquired infections, including pneumonia and infections involving resistant pathogens like MRSA and vancomycin-resistant enterococci. Its ability to evade common resistance mechanisms makes it a valuable option in critical care settings.