Used in the treatment and management of HIV infection as part of antiretroviral therapy. It helps reduce viral load and slow disease progression. Also used for chronic hepatitis B treatment by inhibiting viral replication. Commonly formulated in oral tablets and often combined with other antiretrovirals for enhanced efficacy. Its prodrug forms improve bioavailability and cellular uptake. Widely used in both therapeutic and preventive settings, including pre-exposure prophylaxis (PrEP) to reduce the risk of HIV acquisition in high-risk individuals.