Used primarily in ophthalmic preparations to treat bacterial infections of the eye, such as conjunctivitis and blepharitis. It is effective against a range of Gram-positive and Gram-negative bacteria due to its ability to inhibit bacterial synthesis of folic acid. Commonly found in eye drops and ointments, it is also used in topical formulations for skin conditions like acne vulgaris and seborrheic dermatitis, particularly when associated with bacterial involvement. Its anti-inflammatory and antimicrobial properties make it suitable for use in combination products with corticosteroids to manage both infection and inflammation.