Used primarily as an acaricide and insecticide in agriculture, targeting mites and sucking insects such as whiteflies, spider mites, and aphids. It is effective in controlling pests on crops like tomatoes, cotton, citrus, and ornamentals. Spiromesifen works by inhibiting lipid biosynthesis, disrupting the development of immature pest stages, which makes it especially useful in integrated pest management programs. Due to its translaminar movement in plant tissues, it provides effective control even on untreated leaf surfaces. It is often applied in rotation with other modes of action to reduce the risk of resistance development.