Used primarily in the treatment of severe acne, especially nodular acne that has not responded to other therapies. It works by reducing the size and activity of sebaceous glands, decreasing oil production, and preventing the formation of new acne lesions. Also utilized in the management of certain skin disorders like keratinization abnormalities. Investigated for its potential in cancer treatment due to its role in cell differentiation and growth regulation, particularly in neuroblastoma and other solid tumors. Requires careful monitoring due to high potential for teratogenicity and other systemic side effects.