Pyrazinamide
10mM in DMSO
Reagent
Code: #224062
CAS Number
98-96-4
blur_circular Chemical Specifications
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Molecular Information
Weight
123.11 g/mol
Formula
C₅H₅N₃O
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Registry Numbers
MDL Number
MFCD00006132
thermostat
Physical Properties
Melting Point
189-191 °C
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Storage & Handling
Storage
-20°C
description Product Description
Used in the treatment of tuberculosis, this compound is a key component of first-line anti-TB therapy. It works effectively against dormant Mycobacterium tuberculosis bacteria, especially in acidic environments such as those found within macrophages. Its main role is to shorten the duration of treatment in combination regimens, making it essential in directly observed therapy short-course (DOTS) programs. It is particularly active during the initial intensive phase of treatment, helping to reduce the bacterial load quickly. Due to its unique mechanism of action, it contributes to preventing relapse and the development of drug resistance when used with other antituberculosis agents like isoniazid and rifampicin.
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