Used primarily to reverse opioid overdose, it acts quickly to block opioid receptors in the brain, restoring normal breathing and consciousness in someone whose breathing has slowed or stopped due to opioid toxicity. It is commonly administered in emergency settings, often as an injection or nasal spray, by first responders, healthcare providers, and even laypeople trained in its use. Because of its life-saving potential, naloxone is widely distributed in community programs aimed at reducing opioid-related deaths. It has no effect on individuals who do not have opioids in their system, making it safe to use in suspected overdose cases. Repeated doses may be needed due to its shorter duration of action compared to some opioids.