Used primarily for the prevention and treatment of malaria, especially in regions where chloroquine resistance is prevalent. It is effective against Plasmodium falciparum and Plasmodium vivax species. Taken orally, it is commonly prescribed for travelers visiting malaria-endemic areas. It has a long half-life, allowing for weekly dosing, which improves compliance. In some cases, it is also used in combination therapies for acute malaria treatment. Due to potential neuropsychiatric side effects, it is not recommended for long-term use or for individuals with a history of mental health disorders.