Used as a prodrug in hormone replacement therapy to treat symptoms of estrogen deficiency in women, such as hot flashes, vaginal dryness, and osteoporosis. It provides a sustained release of estradiol due to the valerate ester prolonging its action. Commonly administered via intramuscular injection for both medical and veterinary applications. Also utilized in the formulation of contraceptives and in the management of certain hormone-sensitive cancers under medical supervision.