Used in hormone replacement therapy to treat symptoms of estrogen deficiency in women, such as hot flashes, vaginal dryness, and osteoporosis. It is also applied in the management of certain menstrual disorders and in some cases of breast cancer in postmenopausal women. Due to its esterified form, it provides a slower release and prolonged activity when administered via intramuscular injection. Commonly found in veterinary medicine for growth promotion in livestock, though this use is regulated in many countries. Also utilized in research settings to study estrogen receptor activity and hormonal pathways.