Ezetimibe is primarily used to lower elevated levels of low-density lipoprotein (LDL) cholesterol in the blood. It works by inhibiting the absorption of cholesterol in the small intestine, which leads to a reduction in circulating LDL cholesterol. It is commonly prescribed as an adjunct to diet and statin therapy for patients with primary hypercholesterolemia. Ezetimibe is also used in the management of homozygous familial hypercholesterolemia, where it helps reduce cholesterol levels when used alongside other lipid-lowering treatments. Additionally, it may be beneficial in reducing the risk of cardiovascular events in high-risk patients by improving overall lipid profiles.