Diacetone alcohol is widely used as a solvent in various industrial and commercial applications. It is particularly effective in coatings, inks, and adhesives due to its ability to dissolve a wide range of substances while evaporating at a controlled rate. Its slow evaporation makes it ideal for use in cellulose nitrate and acrylic coatings, where it helps improve flow and leveling.

It is commonly found in paint removers and cleaning formulations because it can soften and break down tough residues without damaging underlying surfaces. In the electronics industry, it serves as a cleaning agent for circuit boards and precision equipment.

Diacetone alcohol is also used in the formulation of cosmetics and personal care products, such as nail polish removers and skin cleansers, thanks to its mild solvent properties and low irritation potential. Additionally, it acts as an intermediate in the synthesis of other chemicals, including pharmaceuticals and agrochemicals.