Used primarily as an antidepressant in the treatment of major depressive disorder and anxiety disorders. It is also prescribed at lower doses for the management of insomnia due to its strong sedative properties. Commonly utilized in patients with comorbid depression and sleep disturbances. Additionally, it is effective in treating certain types of chronic pain, including neuropathic pain, and is sometimes used off-label for conditions like pruritus (itching), especially in patients with atopic dermatitis or uremic pruritus due to its potent antihistaminic effects. Available in oral and topical formulations, with the topical form specifically developed for localized relief of itch without significant systemic absorption.