Used in hormone replacement therapy to manage symptoms of estrogen deficiency in women, particularly after menopause. It provides long-lasting estrogenic effects due to its depot formulation, which allows slow release after intramuscular injection. Commonly prescribed for hot flashes, vaginal atrophy, and prevention of osteoporosis in postmenopausal women. Also used in the treatment of certain gynecological disorders and in transgender hormone therapy to promote feminization.