Used primarily in the treatment of obsessive-compulsive disorder (OCD) in adults. It is also prescribed for major depressive disorder, particularly when other antidepressants have not been effective. Has activity in managing chronic pain conditions such as neuropathic pain due to its effect on central pain pathways. Sometimes utilized off-label for treating certain anxiety disorders, panic attacks, and cataplexy associated with narcolepsy. In veterinary medicine, it is employed to address behavioral issues in dogs and cats, such as separation anxiety and compulsive behaviors.