Trihydroxyethylrutin is widely used in the pharmaceutical and cosmetic industries due to its antioxidant and anti-inflammatory properties. In medicine, it is employed to strengthen blood vessels, reduce capillary fragility, and improve microcirculation, making it beneficial in treating conditions like chronic venous insufficiency and hemorrhoids. It is also utilized in formulations aimed at reducing edema and inflammation.

In skincare products, it is valued for its ability to protect the skin from oxidative stress caused by UV radiation and environmental pollutants. It helps in reducing redness, soothing irritated skin, and enhancing the skin's overall resilience. Additionally, its anti-aging properties make it a common ingredient in serums and creams designed to combat wrinkles and improve skin elasticity.

Its versatility and efficacy in both therapeutic and cosmetic applications have made it a popular choice in various formulations.