Piperonylbutoxide is widely used as a synergist in insecticide formulations, enhancing the effectiveness of active ingredients like pyrethrins and pyrethroids. It is commonly applied in household insecticides, agricultural pest control, and public health programs to combat mosquitoes and other disease-carrying insects. Additionally, it is utilized in pet care products to manage fleas and ticks. Its role in increasing the potency of insecticides allows for lower doses of active ingredients, reducing environmental impact and cost. Piperonylbutoxide is also found in some industrial applications for protecting stored products from insect damage.