Nicotinamide is widely used in skincare products due to its anti-inflammatory properties, making it effective in treating acne, rosacea, and other skin conditions. It helps improve the skin barrier function, reduces redness, minimizes pore appearance, controls sebum production, and boosts collagen synthesis for smoother, more youthful skin. Additionally, it is used in formulations to address hyperpigmentation and uneven skin tone by inhibiting melanin transfer to skin cells.

In the medical field, it is utilized as a dietary supplement to treat niacin deficiency, which can lead to pellagra, a condition characterized by dermatitis, diarrhea, and dementia. It is also being researched for its potential role in managing diabetes, as it may help preserve pancreatic beta-cell function and improve insulin sensitivity. Furthermore, nicotinamide supports overall health, including nervous system and brain function.

Nicotinamide has shown promise in cancer prevention studies, particularly in reducing the risk of non-melanoma skin cancers when taken orally. Its ability to enhance DNA repair and modulate immune responses contributes to its protective effects. In ophthalmology, it is explored for its potential to slow the progression of glaucoma by protecting retinal ganglion cells from damage.