Acitretin is primarily used in the treatment of severe psoriasis, particularly plaque psoriasis, where it helps to normalize skin cell growth and reduce inflammation. It is also effective in treating other skin disorders such as ichthyosis and Darier’s disease. In some cases, it is prescribed off-label for conditions like lichen planus or cutaneous T-cell lymphoma. The medication is often used when other treatments, such as topical therapies or phototherapy, have not provided sufficient relief. Due to its teratogenic potential, it is strictly contraindicated in women who are pregnant or planning to conceive. Patients are usually monitored for potential side effects, including dry skin, elevated lipid levels, and liver function abnormalities, during the course of treatment.