4-(((7-Oxo-6,7-dihydro-8H-thiazolo[5,4-e]indol-8-ylidene)methyl)amino)-N-(pyridin-2-yl)benzenesulfonamide
98%
Reagent
Code: #220964
CAS Number
222036-17-1
blur_circular Chemical Specifications
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Molecular Information
Weight
449.5 g/mol
Formula
C₂₁H₁₅N₅O₃S₂
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Registry Numbers
MDL Number
MFCD03452930
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Storage & Handling
Density
1.635±0.06 g/cm3(Predicted)
Storage
-20°C, Sealed, Dry
description Product Description
Used in research as a potent and selective inhibitor of cyclin-dependent kinases (CDKs), particularly CDK2 and CDK9, making it a valuable tool in studies related to cell cycle regulation and transcription in cancer biology. It shows promise in preclinical models for suppressing tumor growth by inducing cell cycle arrest and apoptosis. Its structure allows for strong binding to the ATP-binding site of CDKs, enhancing its inhibitory activity. Also employed in biochemical assays to probe kinase signaling pathways and assess the therapeutic potential of CDK inhibition in diseases like leukemia and solid tumors.
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