Used primarily in research settings for its potent and irreversible alpha-adrenergic blocking activity. It is especially valuable in studies involving adrenergic receptors due to its long-lasting effects, making it suitable for receptor binding and functional assays. Its (R)-enantiomer exhibits higher selectivity and potency compared to the racemic mixture, allowing for more precise pharmacological profiling. Commonly employed in cardiovascular research to investigate mechanisms of vasodilation, hypertension, and sympathetic nervous system regulation. Also utilized in radiolabeled form to map and quantify alpha-adrenergic receptor distribution in tissues. Due to its irreversible binding, it enables permanent receptor inactivation, which is useful in turnover and regeneration studies of receptor populations.