Manidipine is primarily used as an antihypertensive agent, effectively managing high blood pressure by relaxing blood vessels and improving blood flow. It is particularly beneficial for patients with mild to moderate hypertension, often prescribed when other treatments are not suitable. Additionally, it is sometimes used in managing chronic kidney disease, as it helps reduce proteinuria and slows kidney damage progression. Its long-acting nature allows for once-daily dosing, improving patient compliance. Manidipine is also noted for its minimal impact on heart rate, making it a preferred choice for hypertensive patients with coexisting cardiovascular conditions.