(S)-(-)-Tolvaptan
Reagent
Code: #232752
CAS Number
331947-44-5
blur_circular Chemical Specifications
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Molecular Information
Weight
448.94 g/mol
Formula
C₂₆H₂₅ClN₂O₃
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Registry Numbers
MDL Number
MFCD30719678
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Physical Properties
Melting Point
157-164 °C
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Storage & Handling
Storage
-20°C
description Product Description
Used primarily in the treatment of hyponatremia (low sodium levels in the blood), especially in patients with heart failure, liver cirrhosis, or syndrome of inappropriate antidiuretic hormone secretion (SIADH). It works by blocking the action of vasopressin in the kidneys, promoting the excretion of free water without significant electrolyte loss. This selective V2 receptor antagonism helps increase serum sodium concentration. Also indicated for slowing kidney cyst growth and decline in kidney function in adults with autosomal dominant polycystic kidney disease (ADPKD). Its aquaretic effect makes it valuable in managing fluid overload without causing substantial diuresis of electrolytes.
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