(3R,5S,E)-7-(4-(4-fluorophenyl)-2-((2-hydroxy-N,2-dimethylpropyl)sulfonamido)-6-isopropylpyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid
98%
science Other reagents with same CAS 1714147-47-3
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description Product Description
This compound is a key intermediate in the synthesis of potent cholesterol-lowering agents, specifically statins like rosuvastatin, which function as inhibitors of HMG-CoA reductase, a critical enzyme in cholesterol biosynthesis. It enables the production of drugs that effectively reduce low-density lipoprotein (LDL) cholesterol levels in the bloodstream, serving as a vital component in the management of hypercholesterolemia and the prevention of cardiovascular diseases such as atherosclerosis, heart attack, and stroke. The intermediate's structure supports high affinity to the target enzyme in the final drug and contributes to improved metabolic stability, high potency, and prolonged action. It is used in the manufacturing of pharmaceuticals prescribed in chronic treatment regimens to enhance overall lipid profiles by modestly increasing high-density lipoprotein (HDL) cholesterol and lowering triglycerides.
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