Esaxerenone is primarily used in the treatment of hypertension and edema associated with heart failure. It functions as a selective mineralocorticoid receptor antagonist, helping to reduce blood pressure by blocking the effects of aldosterone, a hormone that regulates salt and water balance in the body. This makes it particularly effective in managing conditions where excess fluid retention and high blood pressure are concerns. Additionally, it is being investigated for its potential benefits in treating chronic kidney disease, as it may help protect kidney function by reducing proteinuria and slowing disease progression. Its targeted action on mineralocorticoid receptors offers a therapeutic advantage with a lower risk of hyperkalemia compared to other similar medications.