Creoside III is primarily used in the treatment of cardiovascular conditions due to its positive inotropic effects, meaning it helps strengthen the force of heart muscle contractions. It is employed in managing certain types of heart failure where enhanced cardiac output is required. The compound supports heart function by inhibiting the sodium-potassium ATPase pump, leading to increased intracellular calcium levels and improved myocardial contractility. It may also be used in specific clinical settings to regulate certain arrhythmias, although its use requires careful monitoring due to a narrow therapeutic index. Ongoing research explores its potential anti-cancer properties, particularly in targeting tumor cell proliferation through ion transport modulation.