Tributyl orthoformate is primarily used as a reagent in organic synthesis, particularly in the formation of acetals and esters. It serves as a protecting group for aldehydes and ketones during complex chemical reactions, ensuring specific functional groups remain unaffected. In the pharmaceutical industry, it is employed in the synthesis of various drug intermediates, aiding in the development of active pharmaceutical ingredients (APIs). Additionally, it finds application in the production of specialty chemicals, such as fragrances and flavors, where it acts as a key building block. Its role in facilitating esterification reactions also makes it valuable in polymer and resin manufacturing processes.