D-Gluconic acid solution is widely used in the food and beverage industry as an acidulant and flavor enhancer due to its mild acidity and good solubility. It helps control pH and acts as a chelating agent, improving the stability of products such as dairy items, beverages, and processed foods.

In the pharmaceutical sector, it is used in formulations requiring gentle acidity, including oral and topical medications. Its biocompatibility makes it suitable for use in wound care products and as a component in some drug delivery systems.

The construction industry utilizes D-gluconic acid solution as a concrete admixture. It acts as a retarding agent, slowing down the setting time of concrete in hot weather and improving workability without compromising strength.

It is also employed in cleaning and descaling agents, especially for metal surfaces, where it effectively removes rust and scale without causing corrosion, thanks to its ability to chelate metal ions like iron and calcium.

In agriculture, it serves as a nutrient source in foliar fertilizers, enhancing the uptake of essential minerals by plants. Its role in improving bioavailability of micronutrients contributes to better crop growth and yield.